Cloning and heterologous expression of Plasmodium ovale dihydrofolate reductase-thymidylate synthase gene

Plasmodial bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) is a validated antimalarial drug target. In this study, expression of the putative dhfr-ts of Plasmodium ovale rescued the DHFR chemical knockout and a TS null bacterial strain, demonstrating its DHFR and TS catalytic fun...

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Detalhes bibliográficos
Main Authors: Tirakarn, Srisuda, Riangrungroj, Pinpunya, Kongsaeree, Palangpon, Imwong, Mallika, Yuthavong, Yongyuth, Leartsakulpanich, Ubolsree
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3444756/
https://ncbi.nlm.nih.gov/pubmed/22234170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.parint.2011.12.004
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