Transgenic Plasmodium parasites stably expressing Plasmodium vivax dihydrofolate reductase-thymidylate synthase as in vitro and in vivo models for antifolate screening

BACKGROUND: Plasmodium vivax is the most prevalent cause of human malaria in tropical regions outside the African continent. The lack of a routine continuous in vitro culture of this parasite makes it difficult to develop specific drugs for this disease. To facilitate the development of anti-P. viva...

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Autori principali: Somsak, Voravuth, Uthaipibull, Chairat, Prommana, Parichat, Srichairatanakool, Somdet, Yuthavong, Yongyuth, Kamchonwongpaisan, Sumalee
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2011
Soggetti:
Methodology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198988/
https://ncbi.nlm.nih.gov/pubmed/21981896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-10-291
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