Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase

Single and multiple mutations at residues 16, 51, 59, 108, and 164 of Plasmodium falciparum dihydrofolate reductase (pfDHFR) have been linked to antifolate resistance in malaria. We prepared and characterized all seven of the pfDHFR mutants found in nature, as well as six mutants not observed in nat...

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Podrobná bibliografie

Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Sirawaraporn, Worachart, Sathitkul, Tanajit, Sirawaraporn, Rachada, Yuthavong, Yongyuth, Santi, Daniel V.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 1997
Témata:	Biological Sciences
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19755/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9037017/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.4.1124
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