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Cloning and heterologous expression of Plasmodium ovale dihydrofolate reductase-thymidylate synthase gene
Plasmodial bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) is a validated antimalarial drug target. In this study, expression of the putative dhfr-ts of Plasmodium ovale rescued the DHFR chemical knockout and a TS null bacterial strain, demonstrating its DHFR and TS catalytic fun...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Elsevier
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3444756/ https://ncbi.nlm.nih.gov/pubmed/22234170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.parint.2011.12.004 |
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