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Artemisinin effectiveness in erythrocyte is reduced by heme and heme-containing proteins
Artemisinin loses its antimalarial activity on prolonged exposure to erythrocytes, especially α-thalassemic erythrocytes. In this report, we show that the major artemisinin-inactivating factor in cytosol of normal erythrocytes was heat-labile but a heat-stable factor from α-thalassemic cells also pl...
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| Glavni autori: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2007
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1949810/ https://ncbi.nlm.nih.gov/pubmed/17498668 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2007.03.008 |
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