Resistance to artemisinin of malaria parasites (Plasmodium falciparum) infecting alpha-thalassemic erythrocytes in vitro. Competition in drug accumulation with uninfected erythrocytes.

Plasmodium falciparum infecting hemoglobin (Hb)H and/or Hb Constant Spring erythrocytes has higher resistance to artemisinin in vitro than when infecting normal erythrocytes. This is due to low drug accumulation of infected erythrocytes resulting from competition with uninfected variant erythrocytes...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Kamchonwongpaisan, S, Chandra-ngam, G, Avery, M A, Yuthavong, Y
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC293858/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8113385/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116994
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