Resistance to artemisinin of malaria parasites (Plasmodium falciparum) infecting alpha-thalassemic erythrocytes in vitro. Competition in drug accumulation with uninfected erythrocytes.

Plasmodium falciparum infecting hemoglobin (Hb)H and/or Hb Constant Spring erythrocytes has higher resistance to artemisinin in vitro than when infecting normal erythrocytes. This is due to low drug accumulation of infected erythrocytes resulting from competition with uninfected variant erythrocytes...

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Опубліковано в::	J Clin Invest
Автори:	Kamchonwongpaisan, S, Chandra-ngam, G, Avery, M A, Yuthavong, Y
Формат:	Artigo
Мова:	Inglês
Опубліковано:	American Society for Clinical Investigation 1994
Предмети:	Research Article
Онлайн доступ:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC293858/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8113385/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116994
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