Biochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase I

BACKGROUND: Antifolates are currently in clinical use for malaria preventive therapy and treatment. The drugs kill the parasites by targeting the enzymes in the de novo folate pathway. The use of antifolates has now been limited by the spread of drug-resistant mutations. GTP cyclohydrolase I (GCH1)...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Kümpornsin, Krittikorn, Kotanan, Namfon, Chobson, Pornpimol, Kochakarn, Theerarat, Jirawatcharadech, Piyaporn, Jaru-ampornpan, Peera, Yuthavong, Yongyuth, Chookajorn, Thanat
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2014
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005822/
https://ncbi.nlm.nih.gov/pubmed/24745605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-13-150
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