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Biochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase I
BACKGROUND: Antifolates are currently in clinical use for malaria preventive therapy and treatment. The drugs kill the parasites by targeting the enzymes in the de novo folate pathway. The use of antifolates has now been limited by the spread of drug-resistant mutations. GTP cyclohydrolase I (GCH1)...
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| Autores principales: | , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
BioMed Central
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4005822/ https://ncbi.nlm.nih.gov/pubmed/24745605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-13-150 |
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