Biochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase I

BACKGROUND: Antifolates are currently in clinical use for malaria preventive therapy and treatment. The drugs kill the parasites by targeting the enzymes in the de novo folate pathway. The use of antifolates has now been limited by the spread of drug-resistant mutations. GTP cyclohydrolase I (GCH1)...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Kümpornsin, Krittikorn, Kotanan, Namfon, Chobson, Pornpimol, Kochakarn, Theerarat, Jirawatcharadech, Piyaporn, Jaru-ampornpan, Peera, Yuthavong, Yongyuth, Chookajorn, Thanat
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2014
Aiheet:
Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005822/
https://ncbi.nlm.nih.gov/pubmed/24745605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-13-150
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