Biochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase I

BACKGROUND: Antifolates are currently in clinical use for malaria preventive therapy and treatment. The drugs kill the parasites by targeting the enzymes in the de novo folate pathway. The use of antifolates has now been limited by the spread of drug-resistant mutations. GTP cyclohydrolase I (GCH1)...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kümpornsin, Krittikorn, Kotanan, Namfon, Chobson, Pornpimol, Kochakarn, Theerarat, Jirawatcharadech, Piyaporn, Jaru-ampornpan, Peera, Yuthavong, Yongyuth, Chookajorn, Thanat
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2014
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005822/
https://ncbi.nlm.nih.gov/pubmed/24745605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-13-150
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