Overexpression of plasmepsin II and plasmepsin III does not directly cause reduction in Plasmodium falciparum sensitivity to artesunate, chloroquine and piperaquine

Artemisinin derivatives and their partner drugs in artemisinin combination therapies (ACTs) have played a pivotal role in global malaria mortality reduction during the last two decades. The loss of artemisinin efficacy due to evolving drug-resistant parasites could become a serious global health thr...

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發表在:Int J Parasitol Drugs Drug Resist
Main Authors: Loesbanluechai, Duangkamon, Kotanan, Namfon, de Cozar, Cristina, Kochakarn, Theerarat, Ansbro, Megan R., Chotivanich, Kesinee, White, Nicholas J., Wilairat, Prapon, Lee, Marcus C.S., Gamo, Francisco Javier, Sanz, Laura Maria, Chookajorn, Thanat, Kümpornsin, Krittikorn
格式: Artigo
語言:Inglês
出版: Elsevier 2018
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6304341/
https://ncbi.nlm.nih.gov/pubmed/30580023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpddr.2018.11.004
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