Combined Spatial Limitation around Residues 16 and 108 of Plasmodium falciparum Dihydrofolate Reductase Explains Resistance to Cycloguanil

Natural mutations of Plasmodium falciparum dihydrofolate reductase (PfDHFR) at A16V and S108T specifically confer resistance to cycloguanil (CYC) but not to pyrimethamine (PYR). In order to understand the nature of CYC resistance, the effects of various mutations at A16 on substrate and inhibitor bi...

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Autores principales: Vanichtanankul, Jarunee, Taweechai, Supannee, Uttamapinant, Chayasith, Chitnumsub, Penchit, Vilaivan, Tirayut, Yuthavong, Yongyuth, Kamchonwongpaisan, Sumalee
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2012
Materias:
Mechanisms of Resistance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393428/
https://ncbi.nlm.nih.gov/pubmed/22526319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00301-12
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