Exploiting Structural Analysis, In Silico Screening and Serendipity to Identify Novel Inhibitors of Drug-resistant Falciparum Malaria

Plasmodium falciparum thymidylate synthase-dihydrofolate reductase (TS-DHFR) is an essential enzyme in folate biosynthesis, and a major malarial drug target. Point mutations in P. falciparum TS-DHFR have caused widespread global antifolate resistance, and yet the most effective antifolate known to o...

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Detalhes bibliográficos
Principais autores: Dasgupta, Tina, Chitnumsub, Penchit, Maneeruttanarungroj, Cherdsak, Kamchonwongpaisan, Sumalee, Nichols, Sara E., Lyons, Theresa M., Tirado-Rives, Julian, Jorgensen, William L., Yuthavong, Yongyuth, Anderson, Karen S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711878/
https://ncbi.nlm.nih.gov/pubmed/19146480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb8002804
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