Lead-optimization of aryl and aralkyl amine based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice

[Image: see text] Malaria is one of the leading causes of severe infectious disease worldwide, yet our ability to maintain effective therapy to combat the illness is continually challenged by the emergence of drug resistance. We previously reported identification of a new class of triazolopyrimidine...

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Detalhes bibliográficos
Main Authors: Gujjar, Ramesh, Mazouni, Farah El, White, Karen L., White, John, Creason, Sharon, Shackleford, David M., Deng, Xiaoyi, Charman, William N., Bathurst, Ian, Burrows, Jeremy, Floyd, David M., Matthews, David, Buckner, Frederick S., Charman, Susan A., Phillips, Margaret A., Rathod, Pradipsinh K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3124361/
https://ncbi.nlm.nih.gov/pubmed/21517059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200265b
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