Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite, Plasmodium falciparum

A Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor that is potent (K(I) = 15 nM) and species-selective (>5,000-fold over the human enzyme) was identified by high-throughput screening. The substituted triazolopyrimidine and its structural analogs were produced by an inexpensi...

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Hlavní autoři: Phillips, Margaret A., Gujjar, Ramesh, Malmquist, Nicholas A., White, John, El Mazouni, Farah, Baldwin, Jeffrey, Rathod, Pradipsinh K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2624570/
https://ncbi.nlm.nih.gov/pubmed/18522386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8001026
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