Analysis of Flavin Oxidation and Electron Transfer Inhibition in Plasmodium falciparum Dihydroorotate Dehydrogenase

Por Malmquist, Nicholas A., Gujjar, Ramesh, Rathod, Pradipsinh K., Phillips, Margaret A.
Publicado em 2008

NO-induced relaxation of labouring and non-labouring human myometrium is not mediated by cyclic GMP

Por Buxton, Iain L O, Kaiser, Robert A, Malmquist, Nicholas A, Tichenor, Stephen
Publicado em 2001

Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum

Por Malmquist, Nicholas A., Moss, Thomas A., Mecheri, Salah, Scherf, Artur, Fuchter, Matthew J.
Publicado em 2012

Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite, Plasmodium falciparum

Por Phillips, Margaret A., Gujjar, Ramesh, Malmquist, Nicholas A., White, John, El Mazouni, Farah, Baldwin, Jeffrey, Rathod, Pradipsinh K.
Publicado em 2008

Comprehensive Histone Phosphorylation Analysis and Identification of Pf14-3-3 Protein as a Histone H3 Phosphorylation Reader in Malaria Parasites

Por Dastidar, Eeshita G., Dzeyk, Kristina, Krijgsveld, Jeroen, Malmquist, Nicholas A., Doerig, Christian, Scherf, Artur, Lopez-Rubio, Jose-Juan
Publicado em 2013

Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical Scaffolds

Por Deng, Xiaoyi, Gujjar, Ramesh, El Mazouni, Farah, Kaminsky, Werner, Malmquist, Nicholas A., Goldsmith, Elizabeth J., Rathod, Pradipsinh K., Phillips, Margaret A.
Publicado em 2009

Development of Diaminoquinazoline Histone Lysine Methyltransferase Inhibitors as Potent Blood-stage Anti-Malarial Compounds

Por Sundriyal, Sandeep, Malmquist, Nicholas A., Caron, Joachim, Blundell, Scott, Liu, Feng, Chen, Xin, Srimongkolpithak, Nitipol, Jin, Jian, Charman, Susan A., Scherf, Artur, Fuchter, Matthew J.
Publicado em 2014

Plasmodium falciparum PfSET7: enzymatic characterization and cellular localization of a novel protein methyltransferase in sporozoite, liver and erythrocytic stage parasites

Por Chen, Patty B., Ding, Shuai, Zanghì, Gigliola, Soulard, Valérie, DiMaggio, Peter A., Fuchter, Matthew J., Mecheri, Salah, Mazier, Dominique, Scherf, Artur, Malmquist, Nicholas A.
Publicado no Sci Rep (2016)

Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)

Por Lucas-Hourani, Marianne, Munier-Lehmann, Hélène, El Mazouni, Farah, Malmquist, Nicholas A., Harpon, Jane, Coutant, Eloi P., Guillou, Sandrine, Helynck, Olivier, Noel, Anne, Scherf, Artur, Phillips, Margaret A., Tangy, Frédéric, Vidalain, Pierre-Olivier, Janin, Yves L.
Publicado no J Med Chem (2015)

Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies

Por Arakaki, Tracy L, Buckner, Frederick S, Gillespie, J Robert, Malmquist, Nicholas A, Phillips, Margaret A, Kalyuzhniy, Oleksandr, Luft, Joseph R, DeTitta, George T, Verlinde, Christophe L M J, Van Voorhis, Wesley C, Hol, Wim G J, Merritt, Ethan A
Publicado em 2008

Histone Methyltransferase Inhibitors Are Orally Bioavailable, Fast-Acting Molecules with Activity against Different Species Causing Malaria in Humans

Por Malmquist, Nicholas A., Sundriyal, Sandeep, Caron, Joachim, Chen, Patty, Witkowski, Benoit, Menard, Didier, Suwanarusk, Rossarin, Renia, Laurent, Nosten, Francois, Jiménez-Díaz, María Belén, Angulo-Barturen, Iñigo, Martínez, María Santos, Ferrer, Santiago, Sanz, Laura M., Gamo, Francisco-Javier, Wittlin, Sergio, Duffy, Sandra, Avery, Vicky M., Ruecker, Andrea, Delves, Michael J., Sinden, Robert E., Fuchter, Matthew J., Scherf, Artur
Publicado no Antimicrob Agents Chemother (2015)