Histone Methyltransferase Inhibitors Are Orally Bioavailable, Fast-Acting Molecules with Activity against Different Species Causing Malaria in Humans

Current antimalarials are under continuous threat due to the relentless development of drug resistance by malaria parasites. We previously reported promising in vitro parasite-killing activity with the histone methyltransferase inhibitor BIX-01294 and its analogue TM2-115. Here, we further character...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Malmquist, Nicholas A., Sundriyal, Sandeep, Caron, Joachim, Chen, Patty, Witkowski, Benoit, Menard, Didier, Suwanarusk, Rossarin, Renia, Laurent, Nosten, Francois, Jiménez-Díaz, María Belén, Angulo-Barturen, Iñigo, Martínez, María Santos, Ferrer, Santiago, Sanz, Laura M., Gamo, Francisco-Javier, Wittlin, Sergio, Duffy, Sandra, Avery, Vicky M., Ruecker, Andrea, Delves, Michael J., Sinden, Robert E., Fuchter, Matthew J., Scherf, Artur
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335868/
https://ncbi.nlm.nih.gov/pubmed/25421480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04419-14
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