Development of Diaminoquinazoline Histone Lysine Methyltransferase Inhibitors as Potent Blood-stage Anti-Malarial Compounds

Modulating epigenetic mechanisms in malarial parasites is an emerging avenue for the discovery of novel antimalarial drugs. Previously we demonstrated the potent in vitro and in vivo antimalarial activity of BIX01294 (1), a known human G9a inhibitor, together with its dose-dependent effects on histo...

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Autori principali: Sundriyal, Sandeep, Malmquist, Nicholas A., Caron, Joachim, Blundell, Scott, Liu, Feng, Chen, Xin, Srimongkolpithak, Nitipol, Jin, Jian, Charman, Susan A., Scherf, Artur, Fuchter, Matthew J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4177335/
https://ncbi.nlm.nih.gov/pubmed/25044750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201402098
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