ADDING A LYSINE MIMIC IN THE DESIGN OF POTENT INHIBITORS OF HISTONE LYSINE METHYLTRANSFERASES

Dynamic histone lysine methylation involves the activities of modifying enzymes (writers), enzymes removing modifications (erasers) and readers of the histone code. One common feature of these activities is the recognition of lysines in methylated and unmethylated states, whether they are substrates...

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Main Authors: Chang, Yanqi, Ganesh, Thota, Horton, John R., Spannhoff, Astrid, Liu, Jin, Sun, Aiming, Zhang, Xing, Bedford, Mark T., Shinkai, Yoichi, Snyder, James P., Cheng, Xiaodong
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895764/
https://ncbi.nlm.nih.gov/pubmed/20434463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.04.048
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