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Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294
We present the crystal structure of the catalytic SET domain of G9a-like protein (GLP) in complex with BIX-01294. The inhibitor is bound in the substrate peptide groove at the location where the histone H3 residues (Lys4 to Arg8) N-terminal to the target lysine would occupy. The inhibitor is positio...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2676930/ https://ncbi.nlm.nih.gov/pubmed/19219047 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1560 |
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