A carregar...
Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294
We present the crystal structure of the catalytic SET domain of G9a-like protein (GLP) in complex with BIX-01294. The inhibitor is bound in the substrate peptide groove at the location where the histone H3 residues (Lys4 to Arg8) N-terminal to the target lysine would occupy. The inhibitor is positio...
Na minha lista:
| Main Authors: | , , , , , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2676930/ https://ncbi.nlm.nih.gov/pubmed/19219047 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1560 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|