Protein lysine methyltransferase G9a acts on non-histone targets

By methylation of peptide arrays, we determined the specificity profile of the protein methyltransferase G9a. We show that it mostly recognizes an Arg-Lys sequence and that its activity is inhibited by methylation of the arginine residue. Using the specificity profile, we identified new non-histone...

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Bibliografiske detaljer
Main Authors: Rathert, Philipp, Dhayalan, Arunkumar, Murakami, Marie, Zhang, Xing, Tamas, Raluca, Jurkowska, Renata, Komatsu, Yasuhiko, Shinkai, Yoichi, Cheng, Xiaodong, Jeltsch, Albert
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2696268/
https://ncbi.nlm.nih.gov/pubmed/18438403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.88
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