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Analysis of the Substrate Specificity of the Dim-5 Histone Lysine Methyltransferase Using Peptide Arrays

Histone methylation is an epigenetic mark essential for gene regulation and development. We introduce peptide SPOT synthesis to study sequence specificity of the Dim-5 histone-3 lysine-9 methyltransferase. Dim-5 recognizes R8-G12 of the H3 tail with T11 and G12 being the most important specificity d...

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Bibliographic Details
Main Authors: Rathert, Philipp, Zhang, Xing, Freund, Christian, Cheng, Xiaodong, Jeltsch, Albert
Format: Artigo
Language:Inglês
Published: 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2723807/
https://ncbi.nlm.nih.gov/pubmed/18215768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2007.11.013
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