Evaluation of Different Virtual Screening Programs for Docking in a Charged Binding Pocket

Por Deng, Wei, Verlinde, Christophe L. M. J.
Publicado em 2008

Reengineering CCA-adding enzymes to function as (U,G)- or dCdCdA-adding enzymes or poly(C,A) and poly(U,G) polymerases

Por Cho, HyunDae D., Verlinde, Christophe L. M. J., Weiner, Alan M.
Publicado em 2007

The Protein Farnesyltransferase Inhibitor Tipifarnib as a new Lead for the Development of Drugs against Chagas Disease

Por Hucke, Oliver, Gelb, Michael H., Verlinde, Christophe L. M. J., Buckner, Frederick S.
Publicado em 2005

Simplified YM-26734 Inhibitors of Secreted Phospholipase A2 Group IIA

Por Oslund, Rob C., Cermak, Nathan, Verlinde, Christophe L. M. J., Gelb, Michael H.
Publicado em 2008

Induced Resistance to Methionyl-tRNA Synthetase Inhibitors in Trypanosoma brucei Is Due to Overexpression of the Target

Por Ranade, Ranae M., Gillespie, J. Robert, Shibata, Sayaka, Verlinde, Christophe L. M. J., Fan, Erkang, Hol, Wim G. J., Buckner, Frederick S.
Publicado em 2013

2-Oxo-tetrahydro-1,8-naphthyridines as Selective Inhibitors of Malarial Protein Farnesyltransferase Inhibitors and as Antimalarials

Por Olepu, Srinivas, Suryadevara, Praveen Kumar, Rivas, Kasey, Yokoyama, Kohei, Verlinde, Christophe L. M. J., Chakrabarti, Debopam, Van Voorhis, Wesley C., Gelb, Michael H.
Publicado em 2007

Inhibitors of Methionyl-tRNA Synthetase Have Potent Activity against Giardia intestinalis Trophozoites

Por Ranade, Ranae M., Zhang, Zhongsheng, Gillespie, J. Robert, Shibata, Sayaka, Verlinde, Christophe L. M. J., Hol, Wim G. J., Fan, Erkang, Buckner, Frederick S.
Publicado no Antimicrob Agents Chemother (2015)

Five Members of a Novel Ca(2+)-binding Protein (CABP) Subfamily with Similarity to Calmodulin

Por Haeseleer, Françoise, Sokal, Izabela, Verlinde, Christophe L. M. J., Erdjument-Bromage, Hediye, Tempst, Paul, Pronin, Alexey N., Benovic, Jeffrey L., Fariss, Robert N., Palczewski, Krzysztof
Publicado em 2000

Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase

Por Aronov, Alex M., Suresh, Stephen, Buckner, Frederick S., Van Voorhis, Wesley C., Verlinde, Christophe L. M. J., Opperdoes, Fred R., Hol, Wim G. J., Gelb, Michael H.
Publicado em 1999

Rod and cone visual cycle consequences of a null mutation in the 11-cis-retinol dehydrogenase gene in man

Por CIDECIYAN, ARTUR V., HAESELEER, FRANÇOISE, FARISS, ROBERT N., ALEMAN, TOMAS S., JANG, GEENG-FU, VERLINDE, CHRISTOPHE L. M. J., MARMOR, MICHAEL F., JACOBSON, SAMUEL G., PALCZEWSKI, KRZYSZTOF
Publicado em 2000

Identification of CD46 Binding Sites within the Adenovirus Serotype 35 Fiber Knob

Por Wang, Hongjie, Liaw, Yen-Chywan, Stone, Daniel, Kalyuzhniy, Oleksandr, Amiraslanov, Imameddin, Tuve, Sebastian, Verlinde, Christophe L. M. J., Shayakhmetov, Dmitry, Stehle, Thilo, Roffler, Steve, Lieber, André
Publicado em 2007

Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design

Por Koh, Cho Yeow, Kim, Jessica E., Napoli, Alberto J., Verlinde, Christophe L.M.J., Fan, Erkang, Buckner, Frederick S., Van Voorhis, Wesley C., Hol, Wim G.J.
Publicado em 2013

Second Generation Analogs of the Cancer Drug Clinical Candidate Tipifarnib for Anti-Chagas Disease Drug Discovery

Por Kraus, James M., Tatipaka, Hari Babu, McGuffin, Sarah A., Chennamaneni, Naveen Kumar, Karimi, Mandana, Arif, Jenifer, Verlinde, Christophe L. M. J., Buckner, Frederick S., Gelb, Michael H.
Publicado em 2010

Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase

Por Eastman, Richard T., White, John, Hucke, Oliver, Yokoyama, Kohei, Verlinde, Christophe L. M. J., Hast, Michael A., Beese, Lorena S., Gelb, Michael H., Rathod, Pradipsinh K., Van Voorhis, Wesley C.
Publicado em 2006

The structure of tryptophanyl-tRNA synthetase from Giardia lamblia reveals divergence from eukaryotic homologs

Por Arakaki, Tracy L, Carter, Megan, Napuli, Alberto J, Verlinde, Christophe L M J, Fan, Erkang, Zucker, Frank, Buckner, Frederick S, Van Voorhis, Wesley C, Hol, Wim G J, Merritt, Ethan A
Publicado em 2010

Distinct states of methionyl-tRNA synthetase indicates inhibitor binding by conformational selection

Por Koh, Cho Yeow, Kim, Jessica E., Shibata, Sayaka, Ranade, Ranae M., Yu, Mingyan, Liu, Jiyun, Gillespie, J. Robert, Buckner, Frederick S., Verlinde, Christophe L.M.J., Fan, Erkang, Hol, Wim G.J.
Publicado em 2012

Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia

Por Larson, Eric T., Kim, Jessica E., Napuli, Alberto J., Verlinde, Christophe L. M. J., Fan, Erkang, Zucker, Frank H., Van Voorhis, Wesley C., Buckner, Frederick S., Hol, Wim G. J., Merritt, Ethan A.
Publicado em 2012

A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens

Por Koh, Cho Yeow, Kallur Siddaramaiah, Latha, Ranade, Ranae M., Nguyen, Jasmine, Jian, Tengyue, Zhang, Zhongsheng, Gillespie, J. Robert, Buckner, Frederick S., Verlinde, Christophe L. M. J., Fan, Erkang, Hol, Wim G. J.
Publicado no Acta Crystallogr D Biol Crystallogr (2015)

Optimization of a binding fragment targeting the “enlarged methionine pocket” leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors

Por Huang, Wenlin, Zhang, Zhongsheng, Ranade, Ranae M., Gillespie, J. Robert, Barros-Álvarez, Ximena, Creason, Sharon A., Shibata, Sayaka, Verlinde, Christophe L. M. J., Hol, Wim G. J., Buckner, Frederick S., Fan, Erkang
Publicado no Bioorg Med Chem Lett (2017)

Dialkylimidazole inhibitors of Trypanosoma cruzi sterol 14α-demethylase as anti-Chagas disease agents

Por Suryadevara, Praveen Kumar, Racherla, Kishore Kumar, Olepu, Srinivas, Norcross, Neil R., Tatipaka, Hari Babu, Arif, Jennifer A., Planer, Joseph D., Lepesheva, Galina, Verlinde, Christophe L. M. J., Buckner, Frederick S., Gelb, Michael H.
Publicado em 2013