Dialkylimidazole inhibitors of Trypanosoma cruzi sterol 14α-demethylase as anti-Chagas disease agents

New dialkylimidazole based sterol 14α-demethylase inhibitors were prepared and tested as potential anti-Trypanosoma cruzi agents. Previous studies had identified compound 2 as the most potent and selective inhibitor against parasite cultures. In addition, animal studies had demonstrated that compoun...

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Detalhes bibliográficos
Main Authors: Suryadevara, Praveen Kumar, Racherla, Kishore Kumar, Olepu, Srinivas, Norcross, Neil R., Tatipaka, Hari Babu, Arif, Jennifer A., Planer, Joseph D., Lepesheva, Galina, Verlinde, Christophe L. M. J., Buckner, Frederick S., Gelb, Michael H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111244/
https://ncbi.nlm.nih.gov/pubmed/24120539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.08.015
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