The structure of tryptophanyl-tRNA synthetase from Giardia lamblia reveals divergence from eukaryotic homologs

The 2.1 Å crystal structure of tryptophanyl-tRNA synthetase (TrpRS) from the diplomonad Giardia lamblia reveals that the N-terminus of this class I aminoacyl-tRNA synthetase forms a 16-residue α-helix. This helix replaces a β-hairpin that is required by human TrpRS for normal activity and has been i...

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Main Authors: Arakaki, Tracy L, Carter, Megan, Napuli, Alberto J, Verlinde, Christophe L M J, Fan, Erkang, Zucker, Frank, Buckner, Frederick S, Van Voorhis, Wesley C, Hol, Wim G J, Merritt, Ethan A
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885457/
https://ncbi.nlm.nih.gov/pubmed/20438846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsb.2010.04.010
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