Induced Resistance to Methionyl-tRNA Synthetase Inhibitors in Trypanosoma brucei Is Due to Overexpression of the Target

New classes of antiparasitic drugs active against Trypanosoma brucei are needed to combat human African trypanosomiasis. Inhibitors of methionyl-tRNA synthetase (MetRS) have excellent potential to be developed for this purpose (S. Shibata, J. R. Gillespie, A. M. Kelley, A. J. Napuli, Z. Zhang, K. V....

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Detalhes bibliográficos
Main Authors: Ranade, Ranae M., Gillespie, J. Robert, Shibata, Sayaka, Verlinde, Christophe L. M. J., Fan, Erkang, Hol, Wim G. J., Buckner, Frederick S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3697344/
https://ncbi.nlm.nih.gov/pubmed/23587950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02578-12
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