Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against Trypanosoma brucei

Based on crystal structures of Trypanosoma brucei methionyl-tRNA synthetase (TbMetRS) bound to inhibitors, we designed, synthesized, and evaluated two series of novel TbMetRS inhibitors targeting this parasite enzyme. One series has a 1,3-dihydro-imidazol-2-one containing linker, the other has a rig...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:RSC Med Chem
Hoofdauteurs: Zhang, Zhongsheng, Barros-Álvarez, Ximena, Gillespie, J. Robert, Ranade, Ranae M., Huang, Wenlin, Shibata, Sayaka, Molasky, Nora M. R., Faghih, Omeed, Mushtaq, Aisha, Choy, Robert K. M., de Hostos, Eugenio, Hol, Wim G. J., Verlinde, Christophe L. M. J., Buckner, Frederick S., Fan, Erkang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Royal Society of Chemistry 2020
Onderwerpen:
Chemistry
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7649832/
https://ncbi.nlm.nih.gov/pubmed/33479683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0md00057d
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items