Development of Methionyl-tRNA Synthetase Inhibitors as Antibiotics for Gram-Positive Bacterial Infections

Antibiotic-resistant bacteria are widespread and pose a growing threat to human health. New antibiotics acting by novel mechanisms of action are needed to address this challenge. The bacterial methionyl-tRNA synthetase (MetRS) enzyme is essential for protein synthesis, and the type found in Gram-pos...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Faghih, Omeed, Zhang, Zhongsheng, Ranade, Ranae M., Gillespie, J. Robert, Creason, Sharon A., Huang, Wenlin, Shibata, Sayaka, Barros-Álvarez, Ximena, Verlinde, Christophe L. M. J., Hol, Wim G. J., Fan, Erkang, Buckner, Frederick S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655057/
https://ncbi.nlm.nih.gov/pubmed/28848016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00999-17
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