Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization

Urea-based methionyl-tRNA synthetase inhibitors were designed, synthesized and evaluated for their potential towards treating human African trypanosomiasis (HAT). With the aid of a homology model and a structure-activity-relationship approach, low nM inhibitors were discovered that show high selecti...

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Hlavní autoři: Shibata, Sayaka, Gillespie, J. Robert, Ranade, Ranae M., Koh, Cho Yeow, Kim, Jessica E., Laydbak, Joy U., Zucker, Frank H., Hol, Wim G. J., Verlinde, Christophe L. M. J., Buckner, Frederick S., Fan, Erkang
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3480199/
https://ncbi.nlm.nih.gov/pubmed/22720744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300303e
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