Metalloproteases Affecting Blood Coagulation, Fibrinolysis and Platelet Aggregation from Snake Venoms: Definition and Nomenclature of Interaction Sites

Por Kini, R. Manjunatha, Koh, Cho Yeow
Publicado no Toxins (Basel) (2016)

Comparison of histidine recognition in human and trypanosomatid histidyl-tRNA synthetases

Por Koh, Cho Yeow, Wetzel, Allan B, de van der Schueren, Will J., Hol, Wim G. J.
Publicado no Biochimie (2014)

Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design

Por Koh, Cho Yeow, Kim, Jessica E., Napoli, Alberto J., Verlinde, Christophe L.M.J., Fan, Erkang, Buckner, Frederick S., Van Voorhis, Wesley C., Hol, Wim G.J.
Publicado em 2013

Crystal Structure of Thrombin in Complex with S-Variegin: Insights of a Novel Mechanism of Inhibition and Design of Tunable Thrombin Inhibitors

Por Koh, Cho Yeow, Kumar, Sundramurthy, Kazimirova, Maria, Nuttall, Patricia A., Radhakrishnan, Uvaraj P., Kim, Seongcheol, Jagadeeswaran, Pudur, Imamura, Takayuki, Mizuguchi, Jun, Iwanaga, Sadaaki, Swaminathan, Kunchithapadam, Kini, R. Manjunatha
Publicado em 2011

Distinct states of methionyl-tRNA synthetase indicates inhibitor binding by conformational selection

Por Koh, Cho Yeow, Kim, Jessica E., Shibata, Sayaka, Ranade, Ranae M., Yu, Mingyan, Liu, Jiyun, Gillespie, J. Robert, Buckner, Frederick S., Verlinde, Christophe L.M.J., Fan, Erkang, Hol, Wim G.J.
Publicado em 2012

A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens

Por Koh, Cho Yeow, Kallur Siddaramaiah, Latha, Ranade, Ranae M., Nguyen, Jasmine, Jian, Tengyue, Zhang, Zhongsheng, Gillespie, J. Robert, Buckner, Frederick S., Verlinde, Christophe L. M. J., Fan, Erkang, Hol, Wim G. J.
Publicado no Acta Crystallogr D Biol Crystallogr (2015)

Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization

Por Shibata, Sayaka, Gillespie, J. Robert, Ranade, Ranae M., Koh, Cho Yeow, Kim, Jessica E., Laydbak, Joy U., Zucker, Frank H., Hol, Wim G. J., Verlinde, Christophe L. M. J., Buckner, Frederick S., Fan, Erkang
Publicado em 2012

Structure-Guided Design of Novel Trypanosoma brucei Methionyl-tRNA Synthetase Inhibitors

Por Huang, Wenlin, Zhang, Zhongsheng, Barros-Álvarez, Ximena, Koh, Cho Yeow, Ranade, Ranae M., Gillespie, J. Robert, Creason, Sharon A., Shibata, Sayaka, Verlinde, Christophe L. M. J., Hol, Wim G. J., Buckner, Frederick S., Fan, Erkang
Publicado no Eur J Med Chem (2016)

5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors

Por Zhang, Zhongsheng, Koh, Cho Yeow, Ranade, Ranae M., Shibata, Sayaka, Gillespie, J. Robert, Hulverson, Matthew A., Huang, Wenlin, Nguyen, Jasmine, Pendem, Nagendar, Gelb, Michael H., Verlinde, Christophe L. M. J., Hol, Wim G. J., Buckner, Frederick S., Fan, Erkang
Publicado no ACS Infect Dis (2016)

Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness

Por Koh, Cho Yeow, Kim, Jessica E., Wetzel, Allan B., de van der Schueren, Will J., Shibata, Sayaka, Ranade, Ranae M., Liu, Jiyun, Zhang, Zhongsheng, Gillespie, J. Robert, Buckner, Frederick S., Verlinde, Christophe L. M. J., Fan, Erkang, Hol, Wim G. J.
Publicado em 2014

Identification of Potent Inhibitors of the Trypanosoma brucei Methionyl-tRNA Synthetase via High Throughput Orthogonal Screening

Por Pedró-Rosa, Laura, Buckner, Frederick S., Ranade, Ranae M., Eberhart, Christina, Madoux, Franck, Gillespie, J. Robert, Koh, Cho Yeow, Brown, Steven, Lohse, Jacqueline, Verlinde, Christophe L. M., Fan, Erkang, Bannister, Thomas, Scampavia, Louis, Hol, Wim G. J., Spicer, Timothy, Hodder, Peter
Publicado no J Biomol Screen (2014)