Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness

Methionyl-tRNA synthetase of Trypanosoma brucei (TbMetRS) is an important target in the development of new antitrypanosomal drugs. The enzyme is essential, highly flexible and displaying a large degree of changes in protein domains and binding pockets in the presence of substrate, product and inhibi...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Koh, Cho Yeow, Kim, Jessica E., Wetzel, Allan B., de van der Schueren, Will J., Shibata, Sayaka, Ranade, Ranae M., Liu, Jiyun, Zhang, Zhongsheng, Gillespie, J. Robert, Buckner, Frederick S., Verlinde, Christophe L. M. J., Fan, Erkang, Hol, Wim G. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990509/
https://ncbi.nlm.nih.gov/pubmed/24743796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002775
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados