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Distinct states of methionyl-tRNA synthetase indicates inhibitor binding by conformational selection
To guide development of new drugs targeting methionyl-tRNA synthetase (MetRS) for treatment of human African trypanosomiasis, crystal structure determinations of Trypanosoma brucei MetRS in complex with its substrate methionine and its intermediate product methionyl-adenylate were followed by those...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3472110/ https://ncbi.nlm.nih.gov/pubmed/22902861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.07.011 |
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