Crystal Structure of Thrombin in Complex with S-Variegin: Insights of a Novel Mechanism of Inhibition and Design of Tunable Thrombin Inhibitors

The inhibition of thrombin is one of the important treatments of pathological blood clot formation. Variegin, isolated from the tropical bont tick, is a novel molecule exhibiting a unique ‘two-modes’ inhibitory property on thrombin active site (competitive before cleavage, noncompetitive after cleav...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Koh, Cho Yeow, Kumar, Sundramurthy, Kazimirova, Maria, Nuttall, Patricia A., Radhakrishnan, Uvaraj P., Kim, Seongcheol, Jagadeeswaran, Pudur, Imamura, Takayuki, Mizuguchi, Jun, Iwanaga, Sadaaki, Swaminathan, Kunchithapadam, Kini, R. Manjunatha
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203879/
https://ncbi.nlm.nih.gov/pubmed/22053189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026367
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados