Crystal Structure of Thrombin in Complex with S-Variegin: Insights of a Novel Mechanism of Inhibition and Design of Tunable Thrombin Inhibitors

The inhibition of thrombin is one of the important treatments of pathological blood clot formation. Variegin, isolated from the tropical bont tick, is a novel molecule exhibiting a unique ‘two-modes’ inhibitory property on thrombin active site (competitive before cleavage, noncompetitive after cleav...

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Main Authors: Koh, Cho Yeow, Kumar, Sundramurthy, Kazimirova, Maria, Nuttall, Patricia A., Radhakrishnan, Uvaraj P., Kim, Seongcheol, Jagadeeswaran, Pudur, Imamura, Takayuki, Mizuguchi, Jun, Iwanaga, Sadaaki, Swaminathan, Kunchithapadam, Kini, R. Manjunatha
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203879/
https://ncbi.nlm.nih.gov/pubmed/22053189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026367
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