A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens

American trypanosomiasis, commonly known as Chagas disease, is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. The chronic form of the infection often causes debilitating morbidity and mortality. However, the current treatment for the disease is typically inadequate...

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Detalles Bibliográficos
Publicado en:Acta Crystallogr D Biol Crystallogr
Main Authors: Koh, Cho Yeow, Kallur Siddaramaiah, Latha, Ranade, Ranae M., Nguyen, Jasmine, Jian, Tengyue, Zhang, Zhongsheng, Gillespie, J. Robert, Buckner, Frederick S., Verlinde, Christophe L. M. J., Fan, Erkang, Hol, Wim G. J.
Formato: Artigo
Idioma:Inglês
Publicado: International Union of Crystallography 2015
Assuntos:
Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528801/
https://ncbi.nlm.nih.gov/pubmed/26249349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1399004715007683
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