A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens

American trypanosomiasis, commonly known as Chagas disease, is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. The chronic form of the infection often causes debilitating morbidity and mortality. However, the current treatment for the disease is typically inadequate...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Acta Crystallogr D Biol Crystallogr
Κύριοι συγγραφείς: Koh, Cho Yeow, Kallur Siddaramaiah, Latha, Ranade, Ranae M., Nguyen, Jasmine, Jian, Tengyue, Zhang, Zhongsheng, Gillespie, J. Robert, Buckner, Frederick S., Verlinde, Christophe L. M. J., Fan, Erkang, Hol, Wim G. J.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: International Union of Crystallography 2015
Θέματα:
Research Papers
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528801/
https://ncbi.nlm.nih.gov/pubmed/26249349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1399004715007683
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