A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens

American trypanosomiasis, commonly known as Chagas disease, is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. The chronic form of the infection often causes debilitating morbidity and mortality. However, the current treatment for the disease is typically inadequate...

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Vydáno v:Acta Crystallogr D Biol Crystallogr
Hlavní autoři: Koh, Cho Yeow, Kallur Siddaramaiah, Latha, Ranade, Ranae M., Nguyen, Jasmine, Jian, Tengyue, Zhang, Zhongsheng, Gillespie, J. Robert, Buckner, Frederick S., Verlinde, Christophe L. M. J., Fan, Erkang, Hol, Wim G. J.
Médium: Artigo
Jazyk:Inglês
Vydáno: International Union of Crystallography 2015
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528801/
https://ncbi.nlm.nih.gov/pubmed/26249349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1399004715007683
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