Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization

Eitemau Tebyg

• Induced Resistance to Methionyl-tRNA Synthetase Inhibitors in Trypanosoma brucei Is Due to Overexpression of the Target
  gan: Ranade, Ranae M., et al.
  Cyhoeddwyd: (2013)
• Structure-Guided Design of Novel Trypanosoma brucei Methionyl-tRNA Synthetase Inhibitors
  gan: Huang, Wenlin, et al.
  Cyhoeddwyd: (2016)
• Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness
  gan: Koh, Cho Yeow, et al.
  Cyhoeddwyd: (2014)
• Optimization of a binding fragment targeting the “enlarged methionine pocket” leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors
  gan: Huang, Wenlin, et al.
  Cyhoeddwyd: (2017)
• Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against Trypanosoma brucei
  gan: Zhang, Zhongsheng, et al.
  Cyhoeddwyd: (2020)