Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)

[Image: see text] Following our discovery of human dihydroorotate dehydrogenase (DHODH) inhibition by 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as well as 2-(4-benzyl-3-ethoxy-5-methyl-1H-pyrazol-1-yl)-5-methylpyridine, we describe here the syntheses and evaluation of an array of azine-bear...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:J Med Chem
Hlavní autoři: Lucas-Hourani, Marianne, Munier-Lehmann, Hélène, El Mazouni, Farah, Malmquist, Nicholas A., Harpon, Jane, Coutant, Eloi P., Guillou, Sandrine, Helynck, Olivier, Noel, Anne, Scherf, Artur, Phillips, Margaret A., Tangy, Frédéric, Vidalain, Pierre-Olivier, Janin, Yves L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2015
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516315/
https://ncbi.nlm.nih.gov/pubmed/26079043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00606
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky