Original Chemical Series of Pyrimidine Biosynthesis Inhibitors That Boost the Antiviral Interferon Response

De novo pyrimidine biosynthesis is a key metabolic pathway involved in multiple biosynthetic processes. Here, we identified an original series of 3-(1H-indol-3-yl)-2,3-dihydro-4H-furo[3,2-c]chromen-4-one derivatives as a new class of pyrimidine biosynthesis inhibitors formed by two edge-fused polycy...

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Bibliografski detalji
Izdano u:Antimicrob Agents Chemother
Glavni autori: Lucas-Hourani, Marianne, Dauzonne, Daniel, Munier-Lehmann, Hélène, Khiar, Samira, Nisole, Sébastien, Dairou, Julien, Helynck, Olivier, Afonso, Philippe V., Tangy, Frédéric, Vidalain, Pierre-Olivier
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2017
Teme:
Antiviral Agents
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5610480/
https://ncbi.nlm.nih.gov/pubmed/28807907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00383-17
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