Discovery of a Broad-Spectrum Antiviral Compound That Inhibits Pyrimidine Biosynthesis and Establishes a Type 1 Interferon-Independent Antiviral State

Viral emergence and reemergence underscore the importance of developing efficacious, broad-spectrum antivirals. Here, we report the discovery of tetrahydrobenzothiazole-based compound 1, a novel, broad-spectrum antiviral lead that was optimized from a hit compound derived from a cytopathic effect (C...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Chung, Dong-Hoon, Golden, Jennifer E., Adcock, Robert S., Schroeder, Chad E., Chu, Yong-Kyu, Sotsky, Julie B., Cramer, Daniel E., Chilton, Paula M., Song, Chisu, Anantpadma, Manu, Davey, Robert A., Prodhan, Aminul I., Yin, Xinmin, Zhang, Xiang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4958224/
https://ncbi.nlm.nih.gov/pubmed/27185801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00282-16
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