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Broad-spectrum antiviral that interferes with de novo pyrimidine biosynthesis

Compound A3 was identified in a high-throughput screen for inhibitors of influenza virus replication. It displays broad-spectrum antiviral activity, and at noncytotoxic concentrations it is shown to inhibit the replication of negative-sense RNA viruses (influenza viruses A and B, Newcastle disease v...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Hoffmann, Hans-Heinrich, Kunz, Andrea, Simon, Viviana A., Palese, Peter, Shaw, Megan L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2011
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078400/
https://ncbi.nlm.nih.gov/pubmed/21436031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1101143108
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