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Identification of a small molecule that primes the type I interferon response to cytosolic DNA
The type I interferon response plays a pivotal role in host defense against infectious agents and tumors, and promising therapeutic approaches rely on small molecules designed to boost this system. To identify such compounds, we developed a high-throughput screening assay based on HEK-293 cells expr...
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| Pubblicato in: | Sci Rep |
|---|---|
| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5451460/ https://ncbi.nlm.nih.gov/pubmed/28566766 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02776-z |
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