Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors

[Image: see text] Malaria is one of the most serious global infectious diseases. The pyrimidine biosynthetic enzyme Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) is an important target for antimalarial chemotherapy. We describe a detailed analysis of protein–ligand interactions betwee...

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Main Authors: Deng, Xiaoyi, Kokkonda, Sreekanth, El Mazouni, Farah, White, John, Burrows, Jeremy N., Kaminsky, Werner, Charman, Susan A., Matthews, David, Rathod, Pradipsinh K., Phillips, Margaret A.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2014
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079327/
https://ncbi.nlm.nih.gov/pubmed/24801997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500481t
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