Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase

অনুরূপ উপাদানগুলি

• Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with anti-malarial activity in mice
  অনুযায়ী: Gujjar, Ramesh, অন্যান্য
  প্রকাশিত: (2009)
• Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors
  অনুযায়ী: Deng, Xiaoyi, অন্যান্য
  প্রকাশিত: (2014)
• Lead-optimization of aryl and aralkyl amine based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice
  অনুযায়ী: Gujjar, Ramesh, অন্যান্য
  প্রকাশিত: (2011)
• Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite, Plasmodium falciparum
  অনুযায়ী: Phillips, Margaret A., অন্যান্য
  প্রকাশিত: (2008)
• Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential
  অনুযায়ী: Coteron, Jose M., অন্যান্য
  প্রকাশিত: (2011)