Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with anti-malarial activity in mice

Plasmodium faliciparum causes 1–2 million deaths annually, yet current drug therapies are compromised by resistance. We previously described potent and selective triazolopyrimidine-based inhibitors of P. falciparum dihydroorotate dehydrogenase (PfDHODH) that inhibited parasite growth in vitro, howev...

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Hlavní autoři: Gujjar, Ramesh, Marwaha, Alka, El Mazouni, Farah, White, John, White, Karen L., Creason, Sharon, Shackleford, David M., Baldwin, Jeffrey, Charman, William N., Buckner, Frederick S, Charman, Susan, Rathod, Pradipsinh K., Phillips, Margaret A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746568/
https://ncbi.nlm.nih.gov/pubmed/19296651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm801343r
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