Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with anti-malarial activity in mice

Lignende værker

• Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase
  af: Marwaha, Alka, et al.
  Udgivet: (2012)
• Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite, Plasmodium falciparum
  af: Phillips, Margaret A., et al.
  Udgivet: (2008)
• Lead-optimization of aryl and aralkyl amine based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice
  af: Gujjar, Ramesh, et al.
  Udgivet: (2011)
• Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors
  af: Deng, Xiaoyi, et al.
  Udgivet: (2014)
• Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy
  af: Phillips, Margaret A., et al.
  Udgivet: (2010)