Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparu...

Por Marwaha, Alka, White, John, El_Mazouni, Farah, Creason, Sharon A, Kokkonda, Sreekanth, Buckner, Frederick S., Charman, Susan A., Phillips, Margaret A., Rathod, Pradipsinh K.
Publicado em 2012

Discovery of N-(2-aminoethyl)-N-benzyloxyphenyl benzamides: New potent Trypanosoma brucei inhibitors

Por Buchynskyy, Andriy, Gillespie, J. Robert, Hulverson, Matthew A., McQueen, Joshua, Creason, Sharon A., Ranade, Ranae M., Duster, Nicole A., Gelb, Michael H., Buckner, Frederick S.
Publicado no Bioorg Med Chem (2016)

Urea Derivatives of 2-Aryl-benzothiazol-5-amines: A New Class of Potential Drugs for Human African Trypanosomiasis

Por Patrick, Donald A., Gillespie, J. Robert, McQueen, Joshua, Hulverson, Matthew A., Ranade, Ranae M., Creason, Sharon A., Herbst, Zackary M., Gelb, Michael H., Buckner, Frederick S., Tidwell, Richard R.
Publicado no J Med Chem (2016)

Optimization of a binding fragment targeting the “enlarged methionine pocket” leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors

Por Huang, Wenlin, Zhang, Zhongsheng, Ranade, Ranae M., Gillespie, J. Robert, Barros-Álvarez, Ximena, Creason, Sharon A., Shibata, Sayaka, Verlinde, Christophe L. M. J., Hol, Wim G. J., Buckner, Frederick S., Fan, Erkang
Publicado no Bioorg Med Chem Lett (2017)

Development of Methionyl-tRNA Synthetase Inhibitors as Antibiotics for Gram-Positive Bacterial Infections

Por Faghih, Omeed, Zhang, Zhongsheng, Ranade, Ranae M., Gillespie, J. Robert, Creason, Sharon A., Huang, Wenlin, Shibata, Sayaka, Barros-Álvarez, Ximena, Verlinde, Christophe L. M. J., Hol, Wim G. J., Fan, Erkang, Buckner, Frederick S.
Publicado no Antimicrob Agents Chemother (2017)

Structure-Guided Design of Novel Trypanosoma brucei Methionyl-tRNA Synthetase Inhibitors

Por Huang, Wenlin, Zhang, Zhongsheng, Barros-Álvarez, Ximena, Koh, Cho Yeow, Ranade, Ranae M., Gillespie, J. Robert, Creason, Sharon A., Shibata, Sayaka, Verlinde, Christophe L. M. J., Hol, Wim G. J., Buckner, Frederick S., Fan, Erkang
Publicado no Eur J Med Chem (2016)

Substituted 2-Phenyl-Imidazopyridines: A New Class of Drug Leads for Human African Trypanosomiasis

Por Tatipaka, Hari Babu, Gillespie, J. Robert, Chatterjee, Arnab K., Norcross, Neil R., Hulverson, Matthew A., Ranade, Ranae M., Nagendar, Pendem, Creason, Sharon A., McQueen, Joshua, Duster, Nicole A., Nagle, Advait, Supek, Frantisek, Molteni, Valentina, Wenzler, Tanja, Brun, Reto, Glynne, Richard, Buckner, Frederick S., Gelb, Michael H.
Publicado em 2014