Substituted 2-Phenyl-Imidazopyridines: A New Class of Drug Leads for Human African Trypanosomiasis

A phenotypic screen of a compound library for antiparasitic activity on Trypanosoma brucei, the causative agent of human African trypanosomiasis, led to the identification of substituted 2-(3-aminophenyl) oxazolopyridines as a starting point for hit-to-lead medicinal chemistry. A total of 110 analog...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Tatipaka, Hari Babu, Gillespie, J. Robert, Chatterjee, Arnab K., Norcross, Neil R., Hulverson, Matthew A., Ranade, Ranae M., Nagendar, Pendem, Creason, Sharon A., McQueen, Joshua, Duster, Nicole A., Nagle, Advait, Supek, Frantisek, Molteni, Valentina, Wenzler, Tanja, Brun, Reto, Glynne, Richard, Buckner, Frederick S., Gelb, Michael H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3962778/
https://ncbi.nlm.nih.gov/pubmed/24354316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401178t
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados